They are probably the best known and most intensively researched mycotoxins in the world. Aflatoxins have been associated with various diseases , such as aflatoxicosis. In susceptible laboratory animals and their acute toxicological effects in humans . As it is realized that absolute safety is never achieved , many countries have attempted to limit exposure to aflatoxins by imposing regulatory limits. A careful survey of t.

C erulenin is an Antifungal antibiotic isolated from Cephalosporium caerulens; Acryocylindrium oryzae; Helicoceras oryzae. Cerulenin Interrupts yeast-type fungi growth by inhibiting the biosynthesis of sterols and fatty acids. Cerulenin Inhibits HMG-CoA synthetase activity. Cerulenin Induces apoptosis in tumor cell lines. Cerulenin should be Protected from light. Cerulenin is hoped to serve as an Inhibitor of fatty acid synthase induced apoptosis in human.

Chromomycin is a Glycosidic antibiotic from streptomyces griseus used as a fluorescent stain of DNA and as an antineoplastic agent. Chromomycin belongs to the DNA-Interactive Drugs.

This mini website about Mitomycin was prepared by a student of BioInformatics, the Open University. Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades. It is an active medicine against many cancers. Mitomycin is a purple color powder, or liquid, and is given by intravenous route only.

Patulin is a polyketide lactone, produced by certain fungal species of Penicillium, Aspergillus and Byssochlamys growing on fruit, including apples, pears, grapes and other fruit. Patulin found to be carcinogenic in lab mamals. Patulin has an Effect on carbohydrate metabolism . patulin Causes breaks in DNA, Inhibits aminoacyl-tRNA synthetase . Patulin has an Influence on intracellular ion flux and interaction with cellular membranes. Patulin has Antitumor activity .

This mini website about Puromycin was prepared by a student of BioInformatics, the Open University. Antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin allows the selection of cells expressing the pac. Gene Puromycin selection works for Gram-positive bacteria and animal cells REF.

This mini website about thapsigargin was prepared by a student of BioInformatics, the Open University. Prostate cancer specific derivatives of thapsigargin. The 10 selected thapsigargin abstracts. Effects of ionomycin and thapsigargin on ion currents in oocytes of Bufo arenarum. Biochemical characterization, distribution and phylogenetic analysis of Drosophila melanogaster ryanodine and IP3 receptors, and thapsigargin-sensitive Ca2 ATPase.

This mini website about Tunicamycin was prepared by a student of BioInformatics, the Open University. Antibiotic useful in glycoprotein research. Inhibitor of N-linked glycosylation and the formation of N-glycosidic protein-carbohydrate linkages. Is an antibiotic that blocks the reaction of UDP-GlcNAc. In the first step of glycoprotein synthesis, thus inhibiting the synthesis of all N-linked glycoproteins. Tunicamycin and Brefeldin A induce in plant cells a programmed cell death showing apoptotic features.